Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Analysis of $\beta$-Blockers in Whole Blood by GC/MS-SIM

  • Rhee, Jong-Sook (National Institute of Scientific Investigation) ;
  • Yang, Hee-Jin (National Institute of Scientific Investigatio) ;
  • Seol, Il-Ung (National Institute of Scientific Investigatio) ;
  • Koo, Ki-Ser (National Institute of Scientific Investigation)
  • Published : 2003.10.01
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Abstract

We describe here solid-extraction and derivatisation methods of ${\beta}$-adrenoceptor blocking drugs used for the treatment of various cardiovascular disorders such as hypertension, angina pectoris and cardiac arrhythmia: propranolol, metoprolol, sotalol, timolol, oxprenolol, alpranolol, atenolol, pindolol. Solid-extraction and derivatisation methods are described involving the use of Bond Elut Certify cartridges, MSTFA and MBTFA. Gas chromatographic-mass spectrometry analysis(GC/MS) was carried out select-ion monitroing mode. (omitted)

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