Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.217.3-217.3
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- 2003
Determination of Acetyl-L-carnitine in human plasma by LC-ESI/MS/MS
- Jang, Moon-Sun (BioCore. Co., LTD.) ;
- Park, Chang-Hun (Seoul Medilcal Science Institute (SCL) ;
- Kim, Ho-Hyun (Seoul Medilcal Science Institute (SCL) ;
- Chang, Kyu-Young (Seoul Medilcal Science Institute (SCL) ;
- Lee, Ye-Rie (Seoul Medilcal Science Institute (SCL) ;
- Lee, Hee-Joo (Seoul Medilcal Science Institute (SCL))
- Published : 2003.10.01
Abstract
Acetyl-L-carnitine, a physiological component of the L-carnitine family, has been proposed for treating Alzheimer's disease in pharmacological doses. Acetyl-L-carnitine and d3-acetylcarnitine (internal standard) were analyzed by electrospray ionization / tandem mass spectrometry (ESI/MS/MS) after derivatization to their butylesters through treatment with butanolic hydrogen chloride. Acetyl-L-carnitine produced a protonated precursor ion at m/z 260 and a corresponding product ion of m/z 85. Analytes were separated on a Capcell Pak C18 (2.0
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