대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- /
- Pages.203.2-204
- /
- 2003
Two acyl phenol glucosides as Inhibitors of iNOS from Popolus davidiana in LPS- activated macrophages
- Kim, Ji-Sun (Sookmyung Women′s University) ;
- Lee, Hwa-Jin (Kookmin University) ;
- Kim, Yong-Kyun (Kookmin University) ;
- Ryu, Jae-Ha (Kookmin University)
- 발행 : 2003.10.01
초록
Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of woody plants and screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. (omitted)
키워드