Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.190.3-190.3
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- 2003
New Cytotoxic Metabolites from a Marine Sponge Homaxinella sp.
- Mansoor Tayyab A. (College of Pharmacy, Pusan National University) ;
- Hong, Jong-Ki (Korea Basic Science Institute) ;
- Lee, Chong-O (Korea Research Institute of Chemical Technolog) ;
- Sim, Chung-Ja (Hannam University) ;
- Im, Kwang-Sik (Hannam University) ;
- Jung, Jee H. (Hannam University)
- Published : 2003.10.01
Abstract
Three new butenolides (1-3), and a new cyclopentenone derivative (4) were isolated from a marine sponge Homaxinella sp. by bioactivity guided fractionation. The gross structures were established on the basis of NMR and MS analyses. The stereochemistry of the butenolides and cyclopentenone derivative was defined on the basis of optical rotation and CD spectroscopy. The compounds were tested against a panel of five human solid tumor cell lines and displayed marginal to significant cytotoxicity.
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