Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.183.2-183.2
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- 2003
Synthesis of 2-Oxo-4-quinolines Using One-pot Reaction for Novel Flavonoid Derivatives
- Park, Myung-Sook (College of Pharmacy, Duksung Women's University) ;
- Kim, Nan-Young (Department of Chemistry, Duksung Women's University) ;
- Park, Hae-Sun (Department of Chemistry, Duksung Women's University) ;
- Kim, Ju-Hee (Department of Chemistry, Duksung Women's University) ;
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Lee, Jae-in
(Department of Chemistry, Duksung Women's University)
- Published : 2003.10.01
Abstract
We report the synthesis of 3,4-dihydro-2-oxo-4-quinolines 5a-e for the development novel flavonoid derivatives with potential antiinflammatory activity and propose a mechanism of the one-pot reaction. The various amines (la-e) for this work were commercially available. We isolated that ester (2a-e) were formed by nucleophilic attraction using ethyl benzoylacetate. The C-N bond formation proceeded at refluxing in toluene with catalytic amount of p-toluenesulfonic acid and a removal of water and ethanol was important in this reaction. (omitted)
Keywords