Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.172.2-173
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- 2003
Protective effects of synthetic of 3-Alkoxy-6-allylthiopyridazine against aflatoxin $B_1$ - induced hepatotoxicity
- Soon, Shin-Hea (College of Pharmacy, Duksung Women's University) ;
-
Kang, Joo-Yeon
(College of Pharmacy, Duksung Women's University)
;
- Park, Myung-Sook (College of Pharmacy, Duksung Women's University) ;
- Kwon, Soon-Kyoung (College of Pharmacy, Duksung Women's University)
- Published : 2003.10.01
Abstract
3-Alkoxy-6-allylthiopyridazine derivatives showed the strongest protective effect against oxidative stress and their anticancer effect determined on the growth of SK-Hep-l hepatocellular carcinomar cells. The allythio group as a pharmacologically active group was introduced into pyridazine nucleus and a substituent such as halogen or alkoxy was also introduced into paraposition of allylthio group. Five kinds of 3-alkoxy-6-allylthiopyridazine derivatives were synthesized and their chemoprotective activities examined in rats exposed to aflatoxin
Keywords