Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.164.1-164.1
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- 2003
Anti-angiogenic activity of wilfoside glycosides isolated from Cynanchum wilfordii
- Kim, Myoung-Sook (Department of Molecular Biology, Pusan National University) ;
- Baek, Jin-Hyen (College of Pharmacy, Seoul National University) ;
- Lee, Hyo-Jong (Korea Research Institute of Bioscience and Biotechnology) ;
- Hwang, Bang-Yeon (Korea Research Institute of Bioscience and Biotechnology) ;
- Kim, Se-Eun (Korea Research Institute of Bioscience and Biotechnology) ;
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Lee, Jung-Joon
(Korea Research Institute of Bioscience and Biotechnology)
;
- Kim, Kyu-Won (Korea Research Institute of Bioscience and Biotechnology)
- Published : 2003.10.01
Abstract
Wm was isolated from Cynanchum wilfordii (Asclepiadaceae) as a mixture form of polypregnane glycosides that included wilfoside K1N and wilfoside C1N. In the present study, we investigated the anti-angiogenic effect of wilfoside glycosides using in vivo and in vitro assay systems. We first demonstrated that concentrated conditioned media obtained from Wm-treated HepG2 human hepatoblastoma cells blocked the angiogenic activation of Wm-untreated concentrated conditioned media, suggesting that Wm may have an inhibitory effect on tumor-induced angiogenesis. (omitted)
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