Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.153.2-154
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- 2003
Eupatilin, a Pharmacologically Active Flavone Derived from Artemisia Plants, Induces Cell Cycle Arrest in Ras-Transformed Human Mammary Epithelial Cells
- Kim, Do-Heeo (College of Pharmacy, Seoul National University) ;
- Na, Hye-Kyung (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Extracts of Artemisia asiatica Nakai (Asteraceae) possess anti-inflammatory and anti-oxidative activities. Eupatilin (5,7-dihydroxy-3,4,6-tri-methoxy-flavone), one of the pharmacologically active ingredients derived from Artemisia asiatica, was shown to induce apoptosis in human promyelocytic leukemia (HL-60) cells (H.-J. Seo and Y.-J. Surh, Mutat. Res., 496, 191-198, 2001). In the present study, we examined the cytostatic effects of eupatilin in H-ras-transformed human breast epithelial (MCF10A-ras) cells. (omitted)
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