Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Expression of $p21^{WAFl/Cip1}$ by $TGF-{\beta}$ Requires ERK Signaling Pathway

  • Kim, Yong-Kee (Dept of Pharmacology, College of Medicine, Kwandong University) ;
  • Bae, Gyu-Un (Dept of Biochem & Mol Biol, Cullege of Pharmacy, Sungkyunkwan University) ;
  • Cho, Eun-Jung (Dept of Pharmacology, College of Medicine, Konyang University) ;
  • Lee, Hoi-Young (Dept of Biochem & Mol Biol, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Hyang-Won (Dept of Biochem & Mol Biol, College of Pharmacy, Sungkyunkwan University) ;
  • Han, Jeung-Whan (Dept of Biochem & Mol Biol, College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.10.01
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Abstract

${\beta}Although$ it has been demonstrated that $p2l^{WAFl/Cip1}$, a well known cell cycle inhibitor, could be induced by $TGF-{\beta}$ in a p53-independent manner, the detailed signal transduction pathways still remain poorly understood. In this study, we show that ERK is required for $TGF-{\beta}$ induction of $p21^{WAF1/Cip1}$, but JNK or p38 MAPK is not. ERK activation by $TGF-{\beta}$ significantly attenuated by treatment with ROS scavenger such as NAC or catalase, indicating that ROS, mainly $H_2O_2$, generation by $TGF-{\beta}$ might stimulate ERK signaling pathway to require the induction of $p21^{WAF1/Cip1}$. (omitted)

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