Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory mechanism of cyclohexylimminobenzoxathiol LYR-64 compound on LPS- induced NO production

  • Kim, Byung-Hak (College of Pharmacy, Chungbuk National University) ;
  • Min, Kyung-Rak (School of Chemical Engineering & Technology, Yeungnam University) ;
  • Lee, Yong-Rok (School of Chemical Engineering & Technology, Yeungnam University) ;
  • Kim, Young-Soo (School of Chemical Engineering & Technology, Yeungnam University)
  • Published : 2003.10.01
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Abstract

Nitric oxide (NO) is known to work as an important signaling molecule involved in regulating a wide range of biological activities in the neuronal, vascular, and immune system. NO and its metabolites mediate a number of host defence functions and are also implicated in the pathogenesis of tissue damage associated with inflammation. Cyclohexylimminobenzoxathiol LYR-64 compound inhibited LPS-induced NO production in murine macrophages Raw264.7 with an IC50 value of 0.7 uM with 95.9% inhibition at 3 uM, 63.5% at 1 uM and 30.2% at 1 uM. (omitted)

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