Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.148.2-149
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- 2003
Potent inhibition of human cytochrome P450 1 enzymes by SY-081
- Kim, Yong-Mo (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Lee, Sang-Kwang (Natural Products Research Institute, Seoul National University) ;
- Kim, Mie-Young (Natural Products Research Institute, Seoul National University) ;
- Kim, Sang-Hee (Natural Products Research Institute, Seoul National University) ;
- Jin, Chun-Young (Natural Products Research Institute, Seoul National University)
- Published : 2003.10.01
Abstract
Recently we have reported that various hydroxystilbenes show strong inhibition of human cytochrome P450 1 enzyme activities. A series of syntheic trans-stilbene derivatives were prepared and their inhibitory potentials were evaluated with the bacterial membrane of recombinant human cytochrome P450 1A1, 1A2 and 1B1 coexpressed with hyman NADPH-P450 reductase to find a new inhibitor of cytochrome P450 enzymes. Of the compounds tested, SY-081 exhibited a potent inhibition of human cytochrome P450 1B1 with an
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