Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.143.1-143.1
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- 2003
Proteomic analysis of nitrated and HNE-adducted proteins in the aging process
- Kim, Chul-Hong (Pusan Bioinformatics & Biocomplexity Research Center, Pusan National University) ;
- Zou, Zou Yani (College of Pharmacy, Pusan National University) ;
- Jung, An-Sung (College of Pharmacy, Pusan National University) ;
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Chung, Hae-Young
(College of Pharmacy, Pusan National University)
- Published : 2003.10.01
Abstract
Peroxynitrite and 4-hydroxynonenal (4-HNE) are highly reactive molecules which are generated under oxidative stress condition and during aging. Many proteins in living organism are modified by them and consequently associated with various diseases including cardiovascular and neurodegenerative diseases. We hypothesize that peroxynitrite and 4-HNE modified serum proteins are also associated with aging process. To establish information on peroxynitrite and 4-HNE adducted proteins for aging study, we used proteins methods, 2D-PAGE and MALD-TOF MS, to identify modified proteins from young (70month) and old (25-month) rat serum. (omitted)
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