Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Release of the Pro-inflammatory Cytokines and Facilitation of Immune Response in LPS-induced Activation of Macrophage by Crude Cordycepin Containing Adenosine(CCCA) from Cordyceps militaris

  • Han, Shin-Ha (Department of Pharmacy, Sahmyook University) ;
  • Lee, Seung-Jeong (CM Riote) ;
  • Song, Young-Cheon (College of Pharmacy, Chungbuk National University) ;
  • Lim, Hee-Jung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Lee, Chong-Kil (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Kwon, Oh-Seung (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Ha, Nam-Joo (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Kim, Kyung-Jae (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The in vitro effects of extracted fractions of C. militaris on the secretion of cytokines in murine macrophage cell line, RAW 264.7 were studied. F1 (crude cordycepin containing adenosine), F2 (ethanol precipitation), F3 (ethanol soluble supernatant) and F4 (fraction of through SK-1B) significantly stimulated the production of cytokine and nitric oxide (NO) on murine macrophage cell line RAW264.7. We examined how the ethanol extract of C. militaris regulates production of interleukine 1-beta(IL-1$\beta$), tumor necrosis factor-alpha (TNF-$\alpha$), and NO in vitro. (omitted)

Keywords