Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
- /
- Pages.118.3-119
- /
- 2003
Rapid Screening Method for the Solid-Phase Extraction and GC/MS analysis of Diazepam.
- Choi, Hwa-Kyung (National Institute of Scientific Investigation) ;
- Lee, Ju-Seon (National Institute of Scientific Investigation) ;
- Choi, Hye-Young (National Institute of Scientific Investigation) ;
- Woo, Sang-Hee (National Institute of Scientific Investigation) ;
- Park, Yoo-Sin (National Institute of Scientific Investigation) ;
- Chung, Hee-Sun (National Institute of Scientific Investigation)
- Published : 2003.10.01
Abstract
Diazepam (DZ) is one of the most frequently prescribed drugs as an antianxiety agent, muscle relaxant, and anticovulsant and sometimes causes intoxication due to accidental overdose, misuse or abuse. Screening or confirmation methods for DZ and NDZ in plasma are very important for clinical and toxicological studies and in forensic cases. GC/MS assay with SPE was developed for the determination of diazepam and its metabolite, nordiazepam in human plasma. Diazepam in plasma was extracted by a rapid and sensitive procedure based on C18 bonded-phase extraction. (omitted)
Keywords