Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.118.1-118.1
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- 2003
Micronucleus test of SS cream and CJ-4001 using Acridine orange staining method
- Park, Jie-Eun (R&D center of Pharmaceuticals, CJ Corporation) ;
- Lee, Sung-Hak (R&D center of Pharmaceuticals, CJ Corporation) ;
- Choi, Jae-Mook (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kim, Il-Hwan (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kim, Taek-Rho (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kim, Deog-Yeor (R&D center of Pharmaceuticals, CJ Corporation) ;
- Noh, Hyun-Jung (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kang, Hee-Chol (R&D center of Pharmaceuticals, CJ Corporation) ;
- Cho, Hi-Jae (R&D center of Pharmaceuticals, CJ Corporation) ;
- Kim, Young-Hoon (R&D center of Pharmaceuticals, CJ Corporation)
- Published : 2003.10.01
Abstract
SS cream and its revised formula, CJ-4001 is topical Chinese herbal drugs for premature ejaculation. To evaluate the genotoxic potentials of these drugs, micronucleus test using Acridine orange (AO) staining method was performed. Acridine orange (AO) staining is adopted in OECD guideline 474 and widely used in micronucleus test. In dose range finding study, no mouse was dead at 2000 mg/kg using single treatment subcutaneously. Therefore, 3 dose levels were chosen at 500, 1000, 2000 mg/kg. (omitted)
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