Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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PC12 and cortical neuron cell death by Bisphenol A through ERK signal pathway : role of estrogen-receptor $\beta$

  • Lee, Yoot-Mo (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Seong, Min-Je (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Lee, Sun-Young (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Lee, Sang-Min (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Kim, Tae-Seong (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Han, Soon-Young (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Yoo, Han-Soo (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Oh, Ki-Wan (College of Pharmacy, Chungbuk National University and KFDA) ;
  • Hong, Jin-Jae (College of Pharmacy, Chungbuk National University and KFDA)
  • Published : 2003.10.01
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Abstract

Bisphenol A (BPA) mimics estrogen and its activity is one third to one quarter that of estradiol. BPA, an ubiquitous environmental contaminent has been shown to cause development reproductive toxicity and carcinogenic effect. BPA may do physiological action through ER$\alpha$ and ER$\beta$ which are expressed in central nerve system. We previously found that expose of BPA to immature mice resulted in behavial alternation, suggesting that overexposure of BPA could be neurotoxic. (omitted)

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