Proteomic Analysis of Cytokine-Like Proteins Secreted from Human Bronchial Epithelial Cells in Response to Pathogenic Bacterial Infection

  • Park, Mi-Ja (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Oh, Mi-Jung (Department of Bioscience & Biotechnology, Sejong University) ;
  • Jo, Dong-Hwan (Department of Bioscience & Biotechnology, Sejong University) ;
  • Chin, Mi-Reyoung (Department of Bioscience & Biotechnology, Sejong University) ;
  • Lee, Ji-Yeon (Department of Bioscience & Biotechnology, Sejong University) ;
  • Park, Ji-Woo (Department of Bioscience & Biotechnology, Sejong University) ;
  • Lee, Na-Gyong (Department of Bioscience & Biotechnology, Sejong University) ;
  • Kim, Dae-Kyong (Department of Bioscience & Biotechnology, Sejong University)
  • Published : 2003.10.01

Abstract

Bacterial infection is a very complex process in which both pathogens and host cells play crucial roles, and the host cells undergo drastic changes in their physiology, releasing various proteins in response to the pathogenic infection. Human airway epithelial surface serves as a first line of defense against microorganisms and the external environment. It is well known that bronchial epithelial cells secrete various chemokines and cytokines such as IL-6 and IL-8 to cope with various respiratory pathogens. (omitted)

Keywords