Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Comparative Study of the Inhibitory Effect of Luteolin and Luteolin-7-Glucoside on Rat Aortic Vascular Smooth Muscle Cell Proliferation

  • Kim, Jin-Ho (College of Pharmacy, Chungbuk National University) ;
  • Kim, Soo-Yeon (School of Agricultural Biotechnology, Seoul National University) ;
  • Lim, Yong (School of Agricultural Biotechnology, Seoul National University) ;
  • Pyo, Hyeong-Bae (School of Agricultural Biotechnology, Seoul National University) ;
  • Park, Byeoung-Soo (School of Agricultural Biotechnology, Seoul National University) ;
  • Yoo, Hwan-Soo (School of Agricultural Biotechnology, Seoul National University) ;
  • Yun, Yeo-Pyo (School of Agricultural Biotechnology, Seoul National University)
  • Published : 2003.10.01
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Abstract

It has been previously reported that luteolin and luteolin-7-glucoside displayed the potent anti-oxidant and anti-inflammatory effects, which have also been successful in reducing vascular smooth muscle cells(VSMCs) proliferation. In this study, a possible anti-proliferative effect and its mechanism on rat aortic VSMCs by luteolin and luteolin-7-glucoside were investigated. Luteolin significantly inhibited the platelet-derived growth factor(PDGF)-BB-induced proliferation of rat aortic VSMCs. While luteolin-7-glucoside weakly inhibited the proliferation. (omitted)

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