Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.101.1-101.1
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- 2003
Honokiol induces apoptosis in activated rat hepatic stellate cells via cytochrome c release and caspase activation
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Park, Eun-Jeon
(Department of Pharmacy, Wonkwang University)
;
- Zhao, Yu-Zhe (College of Pharmacy, Chungnam National University) ;
- Lee, Sung-Hee (College of Pharmacy, Chungnam National University) ;
- Kang, Joo-Yi (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
- Sohn, Dong-Hwan (College of Pharmacy, Chungnam National University)
- Published : 2003.10.01
Abstract
The therapeutic goal in liver fibrosis is to reverse fibrosis and selective clearance of activated hepatic stellate cells (HSCs), which playa central role in liver fibrogenesis, by apoptosis might be essential during resolution of fibrosis. Past several years we screened for natural products which mediate apoptosis in activated HSCs, and among the candidates honokiol, isolated from Magnoliae Cortex, was found to induce apoptotic death in activated rat HSCs in a dose- and time-dependent manner at the concentration between 12.5 microM and 50 microM. (omitted)
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