Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.94.2-94.2
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- 2003
CJ-11668, A new selective and potent COX-2 inhibitor, reduces inflamation, fever and pain in animal models
- Kim, Seong-Woo (Institute of Science & Technology, CJ Corp.) ;
- Park, Hyun-Jung (Institute of Science & Technology, CJ Corp) ;
- Kim, Young-Gi (Institute of Science & Technology, CJ Corp) ;
- Yeon, Kyu-Jeong (Institute of Science & Technology, CJ Corp) ;
- Ryu, Hyung-Chul (Institute of Science & Technology, CJ Corp) ;
- Park, Sang-Wook (Institute of Science & Technology, CJ Corp) ;
- Kim, Jong-Hoon (Institute of Science & Technology, CJ Corp) ;
- Ko, Dong-Hyun (Institute of Science & Technology, CJ Corp) ;
- Chae, Myeong-Yun (Institute of Science & Technology, CJ Corp.)
- Published : 2003.10.01
Abstract
CJ-11668 is a new potent and selective COX-2 inhibitor. CJ-11668 showed COX-2 inhibition (IC50) of 65nM and selectivity ratio (COX-l/COX-2) of 770 in the cell based assay. In the human whole blood assay, CJ-11668 showed COX-2 inhibition (IC50) of 370nM and selectivity ratio (COX-l/COX-2), 135. The treatment of CJ-11668 (5 mg/kg, p.o) produced a significant inhibition (35%) of inflamed rat paw volume in the carrageenan-induced acute inflammation. CJ-11668 also suppressed the PGE2 level (69% inhibition, 1 mg/kg, p.o) in the zymosan-induced mouse air pouch model after 3 hrs. (omitted)
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