Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of chlorhexidine digluconate on thickness of outer membranes isolated from Cultured Porphyromonas gingivalis

  • Jang, Hye-Ock (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Ahn, Ki-Weon (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Shin, Sang-Hun (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Chung, In-Kyo (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Yun, Il (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University)
  • Published : 2003.10.01
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Abstract

To get a better insight into the biophysical mechanism of action of chlorhexidine digluconate, we examined the effect of chlorhexidine digluconate on the thickness of outer membranes isolated from cultured Porphyromonas gingivalis using energy transfer between the membrane surface fluorescent probe (l-anilinonaphthalene-8-sulfonic acid) and the hydrophobic fluorescent probe [1,3-di(l-pyrenyl)propane]. 1-Anilinonaphthalene-8-sulfonic acid quenches the monomer fluorescence of 1,3-di(1-pyrenyl)propane. (omitted)

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