Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
- /
- Pages.88.3-89
- /
- 2003
Acanthoic acid blocks production of pro-inflammatory mediators by inhibiting the ERK activation in trypsin-stimulated human leukemic mast cells
-
Kang, Ok-Hwa
(Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
;
- Tae, Jin (College of Pharmacy, Chllngnam National University) ;
- Choi, Yeon-A (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Kim, Yun-Kyung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Cai, Xing-Fu (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Kim, Young-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Bae, Ki-Hwan (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
-
Lee, Young-Mi
(Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
- Published : 2003.10.01
Abstract
Acanthoic acid (AA) is a pimaradiene diterpene isolated from the Korean medicinal plant, Acanthopanax koreanum (Araliaceae), which has been traditionally used as a tonic and sedative as well as in the treatment of rheumatism and diabetes in korea. Proteinase-activated receptor-2 (PAR-2) agonist trypsin plays a role in inflammation, and human leukemic mast cells (HMC-l) express PAR-2. In the present study, the effect of acanthoic acid on production of tumor necrosis factor-
Keywords