Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Suppression of IL-8 production by 18-beta-Glycyrrhetinic acid is mediated by inhibition of MAPKs and NF-kappaB

  • Choi, Yeon-A (Department of Oriental Pharmacy, College of Pharmacy) ;
  • Kang, Ok-Hwa ( Wonkwang University) ;
  • Kim, Jin-A (Department of Oriental Pharmacy, College of Pharmacy) ;
  • Tae, Jin ( Wonkwang University) ;
  • Kim, Hyun-Mi (Institute of Digestive Disease, Wonkwang University School of Medicin) ;
  • Choi, Suck-Chei (Institute of Digestive Disease, Wonkwang University School of Medicin) ;
  • Lee, Young-Mi (Institute of Digestive Disease, Wonkwang University School of Medicin)
  • Published : 2003.10.01
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Abstract

Intestinal epithelial cells can produce cytokines and chemokines that play an important role in the mucosal immune response. Regulation of this production is important to prevent inflammatory tissue damage. Glycyrrhiza glabra has been shown to inhibit inflammation. The aim of this study was to examine the inhibitory effect of 18- beta-glycyrrhetinic acid, a triterpenoid saponin of Glycyrrhiza glabra, on IL-S production via mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kB) in TNF-alpha-stimulated human colon epithelial cells. (omitted)

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