Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.79.2-79.2
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- 2003
Minocycline Directly Blocks Activation of Caspases After Oxidative Stress in PC12 Cells
- Choi, Yu-Keum (College of Pharmacy, Seoul National University) ;
- Kim, Gab-Seok (College of Pharmacy, Seoul National University) ;
- Han, Byung-Hee (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Minocycline is known to protect neurons from microglia-mediated cell death in many experimental models of brain diseases including ischemic stroke, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), traumatic brain injury, multiple sclerosis, and Parkinson's disease. Activation of caspase-2, 3, 8, and 9 was evident within 2-8 hr following oxidative insult with 0.5 mM hydrogen peroxide in PC12 cells. Minocycline significantly attenuated activation of these caspases up to 18 hr, resulting a significant increase in cell viability as assessed by MTT assay. (omitted)
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