Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.76.2-76.2
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- 2003
Sphingosine-1-phosphate Inhibits Human Keratinocyte Proliferation via Akt/PKB Inactivation
- Kim, Dong-Seok (Research Division for Human Life Sciences, Seoul National University) ;
- Kim, Sook-Young (Department of Dermatology, Seoul National University College of Medicin) ;
- Kim, Kyu-Han (Department of Dermatology, Seoul National University College of Medicin) ;
- Park, Kyoung-Chan (Department of Dermatology, Seoul National University College of Medicine)
- Published : 2003.10.01
Abstract
Although sphingosine-1-phosphate (S1P) is a well-known mitogen, our results show that S1P potently inhibits keratinocyte proliferation, and that this leads the inhibition of DNA synthesis. Interestingly, the prolonged activation of extracellular signal-regulated protein kinase (ERK) and the transient inactivation of Akt/protein kinase B (PKB) were also oberved in concert with the inhibition of keratinocyte proliferation by S1P. To further verify the anti-proliferative action of S1P, we examined changes in cell cycle related proteins. (omitted)
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