Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and characterization of transferrin-polyethylenimine conjugate for targeted gene delivery

  • Lee, Kyung-Man (College of Pharmacy, Chonnam National University) ;
  • Kim, In-Sook (College of Pharmacy, Chonnam National University) ;
  • Shin, Sang-Chul (College of Pharmacy, Chonnam National University) ;
  • Oh, In-Joon (College of Pharmacy, Chonnam National University)
  • Published : 2003.04.01
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Abstract

Polyethylenimine (PEI) has been used as a non-viral gene delivery carrier. To improve the efficacy of transfection, transferrin was incorporated by covalent linkage to PEI. As a model plasmid DNA, pHME185/b-gal, a mammalian expression vector was used. The transferrin-polyethylenimine (TfPEI) was synthesized by conjugate PEI with transferrin using sodium periodateand and characterized by FT-IR and 1H-NMR. (omitted)

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