Effects of Glucose Supplementation on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Water Deprivation for 72 Hours

  • Kim, Yu-Chul (College of Pharmacy, Seoul National University) ;
  • Kim, Eun-Jung (Department of Diagnostic Pathology, College of Medicine, University of Ulsa) ;
  • Lee, In-Chul (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Kim, Sang-Geon (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Lee, Myung-Gull (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Kim, So-Hee (Department of Pharmacology, College of Dentistry, Kangnung National University)
  • Published : 2003.04.01

Abstract

In rats with water deprivation for 72 h (rats with dehydration), hepatic cytochrome P450 2E1 (CYP2E1) was 3-fold induced with an increase in mRNA, and glucose supplementation instead of food during 72-h water deprivation inhibited the CYP2E1 induction. Chlorzoxazone (CZX) is metabolized to 6-hydroxychlorzoxazone (OH-CZX) mainly by CYP2E1 in rats. (omitted)

Keywords