Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Development of analytical method of DMDM hydantoin, Sorbic acid, Phenoxy ethanol in Cosmetics

  • Kim, Young-Ok (Drug Evaluation Department, Korea Food and Drug Administration) ;
  • Jang, Jung-Yun (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Lee, Jeong-Pyo (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Yang, Seong-Jun (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Lee, Kyung-Shin (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Yang, Won-Jun (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Kim, Chong-Kap (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Choi, Sang-Sook (Drug Evaluation Department, Korea Food and Drug Administration)
  • Published : 2003.04.01
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Abstract

A high-performance liquid chromatographic method for the simultaneous quantitative analysis of DMDM hydantoin, sorbic acid, phenoxy ethanol in cosmetics was studied by using a X-terra C18 column and 0.75mM KH2PO4 in 0.85％ sulfuric acid and methanol mixture(7:3) at 214nm. Calibration curves were found to be linear in the 20-100$\mu\textrm{g}$/mL range (DMDM hydantoin), 50-250$\mu\textrm{g}$/mL range (sorbic acid) and 10-50$\mu\textrm{g}$/mL range (phenoxy ethanol). The result of recovery test were 96.6％ - 104.2％. This HPLC method can be applied quality control of cosmetics.

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