Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory activity of diarylheptanoids on farnesyl protein transferase

  • Kang, Hyun-Mi (Korea Research Institute of Bioscience and Biotechnology) ;
  • Jeon, Sun-Bok (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
  • Son, Kwang-Hee (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
  • Yang, Deok-Cho (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
  • Han, Dong-Cho (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
  • Kwon, Byoung-Mog (School of Life Sciences, College of Natural Sciences, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and A new cyclic diarylheptanoiid (6) and a known compound 7 were isolated from fruits of Alnus japonica S. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FTPase) with an IC50 of 29-50 $\mu\textrm{m}$. (omitted)

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