Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.242.1-242.1
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- 2003
Evaluation of L-FMUS as a potent anti-HBV agent
- Woo, Seong-Ju (BUKWANG PHARM, Central Research Institute) ;
- Lee, Hae-Sung (BUKWANG PHARM, Central Research Institut) ;
- Cheong, Min-Young (BUKWANG PHARM, Central Research Institut) ;
- Ahn, Kwang-Hyun (BUKWANG PHARM, Central Research Institut) ;
- Park, Ki-Seok (BUKWANG PHARM, Central Research Institut) ;
- Koo, Chang-Hui (BUKWANG PHARM, Central Research Institute)
- Published : 2003.04.01
Abstract
The nucleoside analogue, L-FMUS was synthesized from L-FMAU which has been shown to have significant antiviral activity against hepatitis B virus (HBV). It was prepared by two steps. First, 5'hydroxyl of L-FMAU was substituted by thioacetyl group using diisopropylazodicarboxylate(DIAD), Triphenyl phosphine(PPh3) and thioacetic acid in anhydrous THF. (omitted)
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