Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.241.3-242
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- 2003
Chain-branched Acyclic Phenethylthiocarbamates as Vanilloid Receptor Antagonists
- Kim, Hee-Doo (Sookmyung Women′s University) ;
- Yoon, Jung-Wha (AmorePacific Co) ;
- Choi, Hye-Young (Seoul National University) ;
- Lee, Hyun-Joo (Seoul National University) ;
- Ryu, Chong-Hyun (Seoul National University) ;
- Park, Young-Ho (Seoul National University) ;
- Suh, Young-Ger (Seoul National University) ;
- Oh, Uh-Taek (Seoul National University) ;
- Park, Hyeung-Guen (Seoul National University)
- Published : 2003.04.01
Abstract
By acting on vanilloid receptor(VR1). capsaicin excites and then desensitizes a subset of primary neurons involved in nociception, neurogenic inflammation, and a variety of local regulatory functions. Due to this unique biological activity, VR1 is at present one of the most attractive targets for the treatment of pain. However, despite the concentrated effort on agonists, they have been exposed to the side effects such as pungency and/or hypothermia responses. (omitted)
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