Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.241.2-241.2
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- 2003
Synthesis of Quinolinones for Novel Flavonoid Derivatives
- Park, Myung-Sook (College of Pharmacy, DukSung Women′s University) ;
- Park, Hae-Sun (College of Pharmacy, DukSung Women′s University) ;
- Yoon, Myung-Sun (College of Pharmacy, DukSung Women′s University) ;
- Kim, Nan-Young (College of Pharmacy, DukSung Women′s University) ;
- Lee, Jae-In (College of Pharmacy, DukSung Women′s University)
- Published : 2003.04.01
Abstract
We report the synthesis of key intermediates for the development novel flavonoid derivatives with potential antiinflammatory activity and propose a mechanism of the one-pot reaction. The various amines (1) for this work were commercially available. Secondary amines (2) were formed by nucleophilic attraction using ethyl benzoylacetate. The C-N bond formation proceeded at refluxing in toluene with catalytic amount of p-toluenesulfonic acid and a removal of water was important in this reaction. (omitted)
Keywords