Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.240.1-240.1
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- 2003
Synthesis of Novel 1-(4-Halophenyl)-5-arylhydantoins as Selective COX-2 Inhibitors
- Kwon, Soon-Kyoung (College of Pharmacy, DukSung Women′s University) ;
- Park, Hae-Sun (College of Pharmacy, DukSung Women′s University) ;
- Choi, Hee-Jeon (College of Pharmacy, DukSung Women′s University) ;
- Park, Myung-Sook (College of Pharmacy, DukSung Women′s University) ;
- Yoon, Myung-Sun (College of Pharmacy, DukSung Women′s University) ;
- Kim, Nan-Young (College of Pharmacy, DukSung Women′s University) ;
- Shin, Hae-Soon (College of Pharmacy, DukSung Women′s University)
- Published : 2003.04.01
Abstract
Nonsteriodal antiinflammatory drugs(NSAIDs) are widely used to treat pain. fever, and inflammatory conditions including osteoarthritis. However, gastrointestinal (GI) and renal toxicity were related to common NSAIDs limits their usefulness because NSAIDs inhibit not only COX-2 associated with anti-inflammatory activity. but also COX-1 accompanied with side effects in the stomach and kidney. (omitted)
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