Synthesis of N-methylspiro [1,2,3,4-tetrahydro-naphthalene-1,2'-pyrrolidine]

  • Jang, Jin-Hee (College of Pharmacy, Kangwon National University) ;
  • Sin, Kwan-Seog (College of Pharmacy, Kangwon National University) ;
  • Park, Hae-Il (College of Pharmacy, Kangwon National University)
  • Published : 2003.04.01

Abstract

A pathway for synthesis of N-methylspiro [1,2,3,4-tetrahydro-naphthalene-1,2'- pyrrolidine] was developed. Formation of the imine compound from ${\alpha}$-tetralone and methylamine using titanium tetrachloride followed by ddition of allylmagnesium bromide gave (1-allyl-1,2,3,4-tetrahydro-naphthalen-1-yl)methylamine. (omitted)

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