A Novel Photonuclease; Bromofluoroacetophenone-Pyrrolecarboxamides

Bromofluoroacetophenone derivatives which produce fluorine substituted phenyl radicals that cleave DNA upon excitation were investigated as a novel photonuclease. Pyrrolecarboxamide-conjugated bromofluoroacetophenones: 4'-bromo-2'-fluoroacetophenone and 2' -bromo-4'-fluoroacetophenone were synthesized and their DNA cleaving activities and sequence selectivities were determined. (omitted)