Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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4-Hydroxy nonenal (HNE) Induces Endothelial cells Apoptosis via iNOS mediated ONOO-generation

  • Chung, Sang-Woon (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yee, Su-Bog (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Choi, Hye-Joung (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Park, Sang-Eun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Jung, Kyung-Jin (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Kim, Dae-Hyun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Chung, Hae-Young (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University)
  • Published : 2003.04.01
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Abstract

Among the aldehydes derived from lipid peroxidation, 4-hydroxynonenal (HNE) that can be produced from arachidonic acids. linoleic acids, or their hydroperoxides in relatively large amounts in response to oxidative insult. Therefore, HNE might be an important mediator of Oxidative stress-induced apoptosis. To study the hypothesis that HNE may induce apoptosis, we estimated cytotoxicity of HNE on YPEN-1 rat prostatic endothelial cells. (omitted)

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