Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The Antiproliferative Effects of Bile Acids and Their Derivatives on HT-29 Human Colon Cancer Cells

  • Park, Sang-Eun (Dept. of Pharmacy, Pusan National University) ;
  • Yee, Su-Bog (Dept. of Pharmacy, Pusan National University) ;
  • Choi, Hye-Joung (Dept. of Pharmacy, Pusan National University) ;
  • Chung, Sang-Woon (Dept. of Pharmacy, Pusan National University) ;
  • Park, Hwa-Sun (Dept. of Pharmacy, Pusan National University) ;
  • Yoo, Young-Hyun (Dept. of Anatomy and Cell Biology, Dong-A University College of Medicine and Institute of Medical Scienc) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Pusan National University)
  • Published : 2003.04.01
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Abstract

The anti proliferative effects of bile acids and their derivatives on HT -29 human colon cancer cells were investigated. Ursodeoxycholic acid (UDCA) and its synthetic derivatives, HS-1030 and HS-1183, and chenodeoxycholic acid (CDCA) and its synthetic derivatives, HS-1199 and HS-1200 were employed for this study. General evaluations focusing on cell cycle were conducted in HT -29 human colon adenocarcinoma cell line (p53 mutant type). (omitted)

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