Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Gestational Exposure to Di(n-butyl)phthalate, flutamide and diethylstilbestrol on Male Reproductive Development in Rats

  • Shin JaeHo (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
  • Moon HyunJu (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim TaeSung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Lee SuJung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kang IlHyun (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim InYoung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Bae Hoon (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Ryu SungYeoul (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Whang SungJo (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA)
  • Published : 2003.04.01
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Abstract

The aims of present study were to compare the effects of in utero exposure to diethylstibestrol (DES), di(n-butyl)phthalate (DBP) and flutamide on the development of reproductive organs and to investigate the specific mechanisms of these abnormalities in the male reproductive system.During gestation days 10-19, pregnant Sparague-Dawley (SD) female rats were administered orally with corn oil (control), DES (25, 50, or 100 ${\mu}$/kg/day), (omitted)

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