Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.182.1-182.1
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- 2003
Cadmium induces neurotoxicity via activation of JNK and c-JUN in human neuroblastoma cell
- Kim, Sun-Don (Division of Brain Disease, Department of Biomedical Science, National Institute of Healt, and College of Pharmacy, Seoul National University) ;
- Moon, C.K. (Division of Brain Disease, Department of Biomedical Science, National Institute of Healt, and College of Pharmacy, Seoul National University) ;
- Jo, Sang-Mee (Division of Brain Disease, Department of Biomedical Science, National Institute of Healt, and College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
Occupational exposure to cadmium (Cd) can result in brain disorders and olfactory dysfunction is the most well-known symptom. Recently Cd has been shown to induce apoptosis by activating MAPKs in various cell types. However, intracellular signaling pathways of Cd-induced cytotoxicity in neuronal cells is not known well. Thus, in the present study, we studied role of JNK and its well-known downstream transcription factor, c-JUN, in Cd-induced neuronal cell death. (omitted)
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