Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.181.2-182
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- 2003
Single and 28-day Repeated Dose Toxicity Studies of Botulinum Toxin Type A in Mice and Rats
- Jeon, Tae-Won (College of Pharmacy, Yeungnam University) ;
- Hyun, Sun-Hee (College of Pharmacy, Yeungnam University) ;
- Kim, Nam-Hee (College of Pharmacy, Yeungnam University) ;
- Lee, Sang-Kyu (College of Pharmacy, Yeungnam University) ;
- Kim, Chun-Hwa (College of Pharmacy, Yeungnam University) ;
- Lee, Dong-Wook (College of Pharmacy, Yeungnam University) ;
- Woo, Hee-Dong (Microbial Toxin Research Institute, Medy- Tox Inc) ;
- Yang, Gi-Hyeok (Microbial Toxin Research Institute, Medy- Tox Inc) ;
- Jung, Hyun-Ho (Division of Applied Biological Sciences, Sunmoon University)
- Published : 2003.04.01
Abstract
Single and 28-day repeated dose toxicity studies of botulinum toxin type A(BTA) were carried out in ICR mice and SD rats. respectively. In the single dose toxicity study. BTA was injected intraperitoneally to male and female mice at a single dose of 40, 59, 89, 133 and 200 ng/kg. All animals died from 59 ng/kg. Some clinical signs were observed in most of both sexes from 59 ng/kg, but no signs were seen in all animals at 40 ng/kg. (omitted)
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