Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effect of skin and seed of Grape and on Dimethylnitrosamine-Induced Liver Damage in Rats

  • Shin, Mi-Ok (College of Pharmacy, Pusan National University) ;
  • Shin, Ji-Young (Department of Anatomy, College of Medicine, Pusan National University) ;
  • Yoon, Sik (Department of Anatomy, College of Medicine, Pusan National University) ;
  • Moon, Jeon-Ok (Department of Anatomy, College of Medicine, Pusan National University)
  • Published : 2003.04.01
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Abstract

Polyphenolic compounds have been reported to exhibit a wide range of pharmacological properties. In this study. we investigated the hepatoprotective effect of skin and seed of grape which contain abundant polyphenol compounds on dimethylnitrosamine(DMN)-induced liver damage in rats. Ingestion of skin and seed of grape (10％ diet, daily for 4 weeks) into the DMN-treated rats remarkably prevented the elevation of serum alanine transaminase, aspartate transaminase and alkaline phosphatase, and bilirubin levels. (omitted)

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