Genotoxicity Study of sophoricoside derivatives in mammalian cells system

  • Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Kim, Eun-Young (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ) ;
  • Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ) ;
  • Jung, Sang-Hun (College of Pharmacy, Chungnam Natl. Univ) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
  • Published : 2003.04.01

Abstract

To develope the novel anti-allergic drug, many sophoricoside derivatives were synthesized. Among these derivatives, JSH-II-3, JSH-Ⅵ-3, JSH-Ⅶ-3, and JSH-Ⅷ-3 were selected and subjected to high throughput toxicity screening (HTTS) because they revealed strong IL-5 inhibitory activity and limitation of Quantity. Mouse lymphoma thymidine kinase ($tk^{+/-}$) gene assay(MOLY) and single cell gel electrophoresis (Comet) assay in mammalian cells were used as HTTS tool in our laboratory. (omitted)

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