Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of adenosine on the development of tolerance to and physical dependence on morphine in mice

  • Kim, Dong-Seuk (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Ahn, Yu-Ri (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (Department of Pharmacology, College of Pharmacy, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

This study was performed to investigate the effects of adenosine on the development of tolerance to and physical dependence on morphine. Repeated adminstration of morphine developed tolerance and physical dependence. Adenosine (1, 2 and 4 mg $kg^{-1}$ i.p.) was administered intraperitoneally to mice for 7 days once a day 30 minutes prior to the morphine (10 mg $kg^{-1}$ s.c.). (omitted)

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