Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibition of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice

  • Shin, Kyung-Wook (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Baik, Jong-Won (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Shin, Im-Chul (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (Department of Pharmacology, College of Pharmacy, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

We examined the effects of glycine on the morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine (10 mg $kg^{-1}$ s.c.) induced hyperactivity as measured in mice. The morphine-induced hyperactivity aws inhibited dose-dependently by the pretreatment with glycine(100, 200 and 400 mg $kg^{-1}$ i.p.). (omitted)

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