An Anti-angiogenic Principle from Gardenia jasminoides.

  • Koo, Hye-Jin (College of Pharmacy, Sookmyung Women′s University) ;
  • Song, Yun-Seon (College of Pharmacy, Sookmyung Women′s University) ;
  • Jin, Chang-Bae (College of Pharmacy, Sookmyung Women′s University) ;
  • Jung, Kyung-Ja (College of Pharmacy, Sookmyung Women′s University) ;
  • Lee, Sang-Hyun (College of Pharmacy, Sookmyung Women′s University) ;
  • Shin, Kuk-Hyun (College of Pharmacy, Sookmyung Women′s University) ;
  • Park, Eun-Hee (College of Pharmacy, Sookmyung Women′s University)
  • Published : 2003.04.01

Abstract

Gardenia jasminoides Ellis has been used in traditional medicine for the treatment of inflammation, jaundice, headache, fever and hypertension. The 70% ethanolic extract of gardenia fruit showed strong anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Among hexane, ethyl acetate, n-butanol and aqueous fractions prepared from the 70% ethanolic extract, the n-butanol fraction was found to be most effective in the CAM assay. (omitted)

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