Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Sauchinone inhibits iNOS, TNF-$\alpha$ and COX-2 induction by LPS

  • Cho, Min-Kyung (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Lee, Ae-Kyung (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Sang-Geon (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Published : 2003.04.01
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Abstract

Sauchinone, a lignan isolated from Saururus chinensis (Saururaceae), is a diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. The effects of sauchinone on the iNOS, TNF-$\alpha$ and COX-2 gene expression and on the activation of transcription factors, NF-$\kappa$B, C/EBP, AP-1 and CREB were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects. (omitted)

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