Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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ROLES OF HUMAN LIVER CYTOCHROMES P450 3A4 AND 1A2 IN THE OXIDATION OF MYRISTICIN

  • Yun, Chul-Ho (Div of Life Sciences, Pai-Chai Univ.) ;
  • Lee, Hye-Suk (College of Pharmacy, Wonkwang Univ) ;
  • Lee, Hee-Yong (Dept of Biochemistry, School of Medicine and Paik-Inje Memorial Institute for Biomedical Science, Inje Univ) ;
  • Yim, Sung-Kun (Dept of Biochemistry, School of Medicine and Paik-Inje Memorial Institute for Biomedical Science, Inje Univ) ;
  • Kim, Keon-Hee (Dept of Biochemistry, School of Medicine and Paik-Inje Memorial Institute for Biomedical Science, Inje Univ) ;
  • Yea, Sung-Su (Dept of Biochemistry, School of Medicine and Paik-Inje Memorial Institute for Biomedical Science, Inje Univ.)
  • Published : 2003.04.01
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Abstract

Myristicin, 1-allyl-3, 4-methylenedioxy-5-methoxybenzene, is a naturally occurring alkenylbenzene compound. It is found in nutmag, mace, parsley, carrot, black pepper, many natural oils and flavoring agents. The aim of this work was to identify the form(s) of human liver cytochrome P450 (P450) involved in the hepatic transformation of myristicin to its major metabolite, 5-allyl-1-methoxy-2, 3-dihydroxybenzene (M1). (omitted)

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