Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.139-140
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- 2003
Protective Effect of Celecoxib, a Selective Cyclooxygenase-2 Inhibitor, Against Beta-Amyloid-Induced Apoptosis: Possible Involvement of Proinflammatory Signals in Beta-Amyloid-Mediated Cell Death
- Jang, Jung-Hee (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Inflammatory as well as oxidative tissue damage has been implicated in pathophysiology of Alzheimer's disease (AD), and non-steroidal anti-inflammatory drugs have been reported to have beneficial effects in the treatment or prevention of AD. In the present study, we investigated the effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on inflammatory cell death induced by beta-amyloid, a neurotoxic peptide associated with senile plaques formed in the brains of patients with AD.(omitted)