Tributyltin Induce Apoptosis by Induction of Nur 77 Expression and Translocation in to the Cytosol in Leydig Cells

  • Park, Chul-Yung (Division of Food Science, Jinju International University) ;
  • Lee, Kyung-Jin (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Kim, Ji-Young (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Oh, Duk-Hee (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Shin, Dong-Weon (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Jung, Kyung-Sik (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Jeong, Hye-Gwang (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University)
  • Published : 2003.10.01

Abstract

Tributyltin (TBT) is also recognized as an endocrine disrupter. Organotin compounds such as TBT are widely used as agricultural biocides, and for antifouling paint of ship bottoms and of fishing nets. In this study, we investigated the role of nur 77 in induction of apoptosis in TBT-induced leydig cells.(omitted)

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