Transcriptional Profile and Cellular Effects on Treatment of Methylmercury Using Human Cdna Microarray

  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Jeon, Hee-Kyung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Chai, Young-Gyu (Department of biochemistry, University of Hanyang) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
  • Published : 2003.10.01

Abstract

Methylmercury is known to have devastating effects on the mammalian nervous system. When human neuroblastoma SH-SY5Y cells were treated with MeHg at sublethal concentrations (6.25 uM), up-regulated genes (39) & Down-regulated genes (19) were identified by microarray.(omitted)

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